Restitution slope is determined by the steady state action potential duration: law and disorder.
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چکیده
Sex in basic research: concepts in the cardiovascular field R. Ventura-Clapier, E. Dworatzek, U. Seeland, G. Kararigas, J.-F. Arnal, S. Brunelleschi, T. C. Carpenter, J. Erdmann, F. Franconi, E. Giannetta, M. Glezerman, S. M. Hofmann, C. Junien, M. Katai, K. Kublickiene, I. R. König, G. Majdic, W. Malorni, C. Mieth, V. M. Miller, R. M. Reynolds, H. Shimokawa, C. Tannenbaum, A. M. D’Ursi, and V. Regitz-Zagrosek 711
منابع مشابه
Restitution slope is principally determined by steady-state action potential duration
Aims The steepness of the action potential duration (APD) restitution curve and local tissue refractoriness are both thought to play important roles in arrhythmogenesis. Despite this, there has been little recognition of the apparent association between steady-state APD and the slope of the restitution curve. The objective of this study was to test the hypothesis that restitution slope is deter...
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We have demonstrated that rate dependent restitution and action potential duration-refractory period hysteresis can be reproduced in a one-dimensional two-variable Chernyak-Starobin-Cohen reaction-diffusion medium with variable excitation threshold. We show that restitution and hysteresis depend on the relationship between pacing period and steady state excitation threshold and also on the rate...
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Hao, Steven C., David J. Christini, Kenneth M. Stein, Peter N. Jordan, Sei Iwai, Orville Bramwell, Steven M. Markowitz, Suneet Mittal, and Bruce B. Lerman. Effect of -adrenergic blockade on dynamic electrical restitution in vivo. Am J Physiol Heart Circ Physiol 287: H390–H394, 2004. First published March 4, 2004; 10.1152/ajpheart.00749.2003.—The slope of the action potential duration (APD) rest...
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Action potential duration and contractility are reduced following premature excitations, and gradually increase as the stimulus interval is lengthened. To examine these phenomena of electrical and mechanical restitution in the human heart, we simultaneously measured action potential duration and the maximum rate of left ventricular pressure in five patients undergoing electrophysiological study...
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If spatial extent is neglected, ionic models of cardiac cells consist of systems of ordinary differential equations (ODEs) which have the property of excitability, i.e., a brief stimulus produces a prolonged evolution (called an action potential in the cardiac context) before the eventual return to equilibrium. Under repeated stimulation, or pacing, cardiac tissue exhibits electrical restitutio...
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ورودعنوان ژورنال:
- Cardiovascular research
دوره 113 7 شماره
صفحات -
تاریخ انتشار 2017